4-HYDROXY-2-QUINOLONES. 97. SIMPLE SYNTHESIS OF THE ESTERS OF 4-HALO-SUBSTITUTED 2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS

Authors

  • И. В. Украинец National Pharmaceutical University, Kharkiv 61002
  • Л. В. Сидоренко National Pharmaceutical University, Kharkiv 61002
  • О. В. Горохова National Pharmaceutical University, Kharkiv 61002
  • С. В. Слободзян Ohio Northern University, Ada, Ohio 45810

DOI:

https://doi.org/10.1007/7889

Keywords:

4-amino-2-oxo-1, 2-dihydroquinolines, enamines, ethyl esters of 4-halo-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids, hydrolysis, decarboxylation

Abstract

Short term treatment of 3-ethoxycarbonyl-4-morpholino-2-oxo-1,2-dihydroquinoline with aqueous solutions of hydrohalogen acids leads to the formation of the ethyl esters of 4-halo-substituted 2-oxo-1,2-dihydroquinoline-3-carboxylic acids. Hydrolysis in HF is possible on extended boiling only to the 4-hydroxy derivative.

How to Cite
Ukrainets, I. V.; Sidorenko, L. V.; Gorokhova, O. V.; Slobodzyan, S. V.  Chem. Heterocycl. Compd. 2006, 42, 882. [Khim. Geterotsikl. Soedin. 2006, 1022.]

For this article in the English edition see DOI 10.1007/s10593-006-0174-3


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Published

2023-06-27

Issue

No. 7 (2006)

Section

Original Papers