SYNTHESIS OF SOME THIADIAZOLES, SELENADIAZOLES AND SPIROHETEROCYCLIC COMPOUNDS FROM THEIR 2,2-DIMETHYLBENZOPYRAN PRECURSORS

Authors

  • N. S. Joshi P.G. Dept. of Chemistry, S. S. G. M. College, Kopargaon, Ahmednagar
  • K. Karale P.G. Dept. of Chemistry, S. S. G. M. College, Kopargaon, Ahmednagar
  • C. H. Gill P.G. Dept. of Chemistry, S. S. G. M. College, Kopargaon, Ahmednagar

DOI:

https://doi.org/10.1007/7991

Keywords:

chromanone, Phosphotyrosine phosphatase 1B, selenadiazole, spiroheterocyclic compounds, thiadiazole

Abstract

New series of 4,4-dimethylbenzopyrano[4,3-d]-1,2,3-selenadiazoles and 4,4-dimethyl-
benzopyrano[4,3-d]-1,2,3-thiadiazoles have been synthesized from semicarbazones of chroman-4-one precursors. Some 4-acetyl-2'-acetylamino-2,2-dimethylspiro[chroman-4,5'-∆2-1,3,4-thia-
diazolines]  have been synthesized by cyclization of thiosemicarbazones of 2,2-dimethylchroman-4-ones using acetic anhydride. The selected compounds were tested for Phosphotyrosine phosphatase 1B inhibition.

How to Cite
Joshi, N. S.; Karale, B. K.; Gill, C. H.  Chem. Heterocycl. Compd. 2006, 42, 681. [Khim. Geterotsikl. Soedin. 2006, 775.]

For this article in the English edition, see DOI 10.1007/s10593-006-0146-7

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Published

2023-08-23

Issue

No. 5 (2006)

Section

Original Papers