4-HYDROXY-2-QUINOLONES. 93. SYNTHESIS AND BIOLOGICAL PROPERTIES OF 2-HYDROXY-4-IMINO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID N-R-AMIDES

Authors

  • И. В. Украинец National Pharmaceutical University, Kharkov 61002
  • Л. В. Сидоренко National Pharmaceutical University, Kharkov 61002
  • О. В. Горохова National Pharmaceutical University, Kharkov 61002
  • Н. А. Джарадат An-Najah National University College of Pharmacy, P.O. Box 7, Nablus

DOI:

https://doi.org/10.1007/8004

Keywords:

4-chloro-2-oxo-1, 2-dihydroquinolines, 2-hydroxy-4-imino-1, 4-dihydroquinolines, amidation, intramolecular cyclization, enamine–imine tautomerism, antitubercular and anti-inflammatory activity

Abstract

Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic acids have been studied. Results of investigations on  the antitubercular and antiinflammatory activity of the obtained compounds are discussed.

How to Cite
Ukrainets, I. V.; Sidorenko, L. V.; Gorokhova, O. V.; Jaradat, N. A.  Chem. Heterocycl. Compd. 2006, 42, 475. [Khim. Geterotsikl. Soedin. 2006, 542.]

For this article in the English edition, see DOI 10.1007/s10593-006-0114-2

 

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Published

2023-08-29

Issue

No. 4 (2006)

Section

Original Papers