CONDENSED ISOQUINOLINES. 19. SYNTHESIS OF 1'-R-SPIRO[6a,11b-DIAZABENZ[<i>e</i>]ACEANTHRYLENE-6(7H),4'(1'H)-PYRIDINE]-5,7(12H)-DIONES

Authors

  • В. М. Кисиль Taras Shevchenko Kiev National University, Kiev 01033
  • Л. М. Потиха Taras Shevchenko Kiev National University, Kiev 01033
  • Р. М. Гуцул Taras Shevchenko Kiev National University, Kiev 01033
  • В. А. Ковтуненко Taras Shevchenko Kiev National University, Kiev 01033
  • А. В. Туров Taras Shevchenko Kiev National University, Kiev 01033

DOI:

https://doi.org/10.1007/8089

Keywords:

isoquinoline, condensed isoquinolines, spiropyridines, spiro compounds, isonicotinoylation, spirocyclization

Abstract

During acylation of 7-isonicotinoyl-6,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one or its alkylation followed by treatment with organic bases, spirocyclization occurs with formation of derivatives of a novel heterocyclic system: 1'-acyl- and 1'-alkylspiro[7H,12H-6a,11b-diazabenz[e]aceanthrylene-6(5H),4'(1'H)-pyridine]-5,7-diones. We have studied  the spectral properties of the synthesized spirans. We have shown that 7-nicotinoyl-6,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one does not undergo an analogous reaction of repeated acylation, while treatment of its quaternary salt with bases leads to a complex mixture of unidentified products.

How to Cite
Kysil, V. M.; Potikha, L. M.; Gutsul, R. M.; Kovtunenko, V. A.; Turov, A. V.  Chem. Heterocycl. Compd. 2006, 42, 100. [Khim. Geterotsikl. Soedin. 2006, 113.]

For this article in the English edition, see DOI 10.1007/s10593-006-0053-y


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Published

2023-09-22

Issue

No. 1 (2006)

Section

Original Papers