SYNTHESIS OF 3-AROYLMETHYLENE-1,6,7,11b-TETRAHYDRO-2H-PYRAZINO[2,1-<i>a</i>]ISOQUINOLIN-4-ONES

Authors

  • В. Л. Гейн Perm State Pharmaceutical Academy, Perm 614990
  • Н. Н. Касимова Perm State Pharmaceutical Academy, Perm 614990
  • Л. И. Варкентин Perm State Pharmaceutical Academy, Perm 614990
  • Г. А. Сташина N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 117913

DOI:

https://doi.org/10.1007/8225

Keywords:

1-aminomethyl-1, 2, 3, 4-tetrahydroisoquinoline, 3-aroylmethylene-1, 6, 7, 11b-tetrahydro-2H-pyrazino[2, 1-a]isoquinolin-4-ones, substituted aroylpyruvate esters

Abstract

The reaction of substituted methyl aroylpyruvates  with 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride in the presence of AcOH gives 3-aroylmethylene-1,6,7,11b-tetrahydro-2H-pyrazino[2,1-a]isoquinolin-4-ones whose structures have been confirmed by IR, 1H NMR, and mass spectrometry.

How to Cite
Gein, V. L.; Kasimova, N. N.; Varkentin, L. I.; Stashina, G. A.  Chem. Heterocycl. Compd. 2005, 41, 1041. [Khim. Geterotsikl. Soedin. 2005, 1218.]

For this article in the English edition, see DOI 10.1007/s10593-005-0276-3

 

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Published

2023-10-30

Issue

No. 8 (2005)

Section

Original Papers