STUDIES ON PYRAZINE DERIVATIVES. 39. SYNTHESIS, REACTIONS, AND TUBERCULOSTATIC ACTIVITY OF 3-PYRAZINYL-1,2,4-TRIAZOLO[4,3-<i>a</i>]-1,3-DIAZACYCLOALKANES

Authors

  • M. Sitarz Departament of Organic Chemistry, Medical University of Gdansk, 80-416 Gdansk
  • H. Foks Departament of Organic Chemistry, Medical University of Gdansk, 80-416 Gdansk
  • M. Janowiec Departament of Microbiology, Institute of Tuberculosis on Pulmonary Diseases, 01-138 Warszawa
  • Z. Zwolska Departament of Microbiology, Institute of Tuberculosis on Pulmonary Diseases, 01-138 Warszawa
  • E. Augustynowicz-Kopeć Departament of Microbiology, Institute of Tuberculosis on Pulmonary Diseases, 01-138 Warszawa

DOI:

https://doi.org/10.1007/8374

Keywords:

S, S’-dimethyldithiocarbonates, pyrazines, 1, 2, 4-triazoles, 4-triazolo[4, 3-a]-1, 3-diazacycloalkanes, acylation, hydroxyalkylation, Mannich reaction, tuberculostatics

Abstract

In the reactions  of S,S’-dimethyldithiocarbamate pyrazinoylhydrazone with diamines some 3-pyrazinyl-1,2,4-triazolo[4,3-a]-1,3-diazacycloalkanes were obtained, and the mechanism of their formation was proposed. The products were acylated, hydroxyalkylated, and aminomethylated. Their tuberculostatic activity was tested in vitro.

How to Cite
Sitarz, M.; Foks, H.; Janowiec, M.; Zwolska, Z.; Augustynowicz-Kopeć, E. Chem. Heterocycl. Compd. 2005, 41, 200. [Khim. Geterotsikl. Soedin. 2005, 230.]

For this article in the English edition, see DOI 10.1007/s10593-005-0128-1

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Published

2023-12-01

Issue

No. 2 (2005)

Section

Original Papers