<i>Candida rugosa</i> LIPASE-CATALYSED KINETIC RESOLUTION OF 3-(ISOBUTYRYLOXY)METHYL 4-[2-(DIFLUOROMETHOXY)PHENYL]-2-METHYL-5,5-DIOXO-1,4-DIHYDROBENZOTHIENO[3,2-<i>b</i>]PYRIDINE-3-CARBOXYLATE

Authors

  • A. Sobolev Latvian Institute of Organic Synthesis, Riga LV 1006
  • R. Zhalubovskis Latvian Institute of Organic Synthesis, Riga LV 1006
  • M. C. R. Franssen Laboratory of Organic Chemistry, Wageningen University, 6703 HB Wageningen
  • B. Vigante Latvian Institute of Organic Synthesis, Riga LV 1006
  • B. Chekavichus Latvian Institute of Organic Synthesis, Riga LV 1006
  • G. Duburs Latvian Institute of Organic Synthesis, Riga LV 1006
  • Ae. de Groot Laboratory of Organic Chemistry, Wageningen University, 6703 HB Wageningen

Keywords:

enantiopure 1,4-dihydropyridines, enzyme-catalysed reaction, kinetic resolution, transesterification

Abstract

The lipase-catalysed kinetic resolution of 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)-phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate has been per-formed. The most enantioselective reaction (E = 28) was a transesterification with n-butanol in water-saturated toluene, at 45 °C.

How to Cite
Sobolev, A.; Zhalubovskis, R.; Franssen, M. C. R.; Vigante, B.; Chekavichus, B.; Duburs, G.; de Groot, Ae. Chem. Heterocycl. Compd. 2004, 40, 931. [Khim. Geterotsikl. Soedin. 2004, 1081.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000044578.17992.95

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Published

2004-07-25

Issue

No. 7 (2004)

Section

Original Papers