ACYLATION OF 3,4-DIHYDROPYRROLO[1,2-<i>a</i>]PYRAZINES

Authors

  • В. И. Теренин M. V. Lomonosov Moscow State University, 119234 Moscow
  • Е. В. Кабанова M. V. Lomonosov Moscow State University, 119234 Moscow
  • Н. А. Целищева M. V. Lomonosov Moscow State University, 119234 Moscow
  • М. А. Ковалкина M. V. Lomonosov Moscow State University, 119234 Moscow
  • А. П. Плешкова M. V. Lomonosov Moscow State University, 119234 Moscow
  • Н. В. Зык M. V. Lomonosov Moscow State University, 119234 Moscow

Keywords:

3,4-dihydropyrrolo[1,2-a]pyrazine, acetylation, trifluoroacetylation

Abstract

The direction of trifluoroacetylation with trifluoroacetic anhydride of 3,4-dihydropyrrolo[1,2-a]-pyrazines containing an alkyl or aralkyl substituent in position 1 depends on both the structure of the 3,4-dihydropyrrolo[1,2-a]pyrazine starting materials and on the ratio of reagent:substrate. It may lead to both mono- and disubstituted products. Trifluoroacetylation of 1-methyl-3,4-dihydropyrrolo[1,2-a]-pyrazines occurs at the methyl group. Acetylation of 3,4-dihydropyrrolo[1,2-a]pyrazines leads only to N-acetyl-substituted reaction products.

How to Cite
Terenin, V. I.; Kabanova, E. V.; Tselishcheva, N. A.; Kovalkina, M. A.; Pleshkova, A. P.; Zyk, N. V. Chem. Heterocycl. Compd. 2004, 40,351. [Khim. Geterotsikl. Soedin. 2004, 431.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000028632.61226.cd

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Published

2004-03-25

Issue

No. 3 (2004)

Section

Original Papers