SYNTHESIS OF 4,5-DIHYDRO-1,3,4-THIADIAZOLE-2-CARBOXAMIDE AND 2-CARBAMOYL-4,5-DIHYDRO-1,3,4-THIADIAZOLE 1-OXIDE DERIVATIVES BASED ON HYDRAZONES OF OXAMIC ACID THIOHYDRAZIDES

Authors

  • В. Н. Яровенко N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991
  • А. В. Широков N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991
  • И. В. Заварзин N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991
  • О. Н. Крупинова N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991
  • A. B. Игнатенко N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991
  • М. М. Краюшкин N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991

Keywords:

hydrazones, 1,3,4-dihydrothiadiazole, dihydro-1,3,4-thiadiazole 1-oxide, 1,3,4-thiadiazole, oxamic acid thiohydrazides, thiophene

Abstract

We have developed a method for obtaining derivatives of 4,5-dihydro-1,3,4-thiadiazole-2-carboxamide by acylation of hydrazones of oxamic acid thiohydrazides. Oxidation of the dihydrothiadiazole ring of the indicated products by hydrogen peroxide leads to formation of 2-carbamoyl-4,5-dihydro-1,3,4-thiadiazole 1-oxides.

How to Cite
Yarovenko, V. N.; Shirokov, A. V.; Zavarzin, I. V.; Krupinova, O. N.; Ignatenko, A. V.; Krayushkin, M. M Chem. Heterocycl. Compd. 2003, 39, 1633. [Khim. Geterotsikl. Soedin. 2003, 1855.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000018342.57499.16

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Published

2003-12-25

Issue

No. 12 (2003)

Section

Original Papers