2-ACYLMETHYL-1H-BENZIMIDAZOLES IN THE BIGINELLI REACTION

Authors

  • И. Б. Дзвинчук Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 02094
  • Т. В. Макитрук Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev
  • М. О. Лозинский Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Kiev 02094

Keywords:

aldehydes, benzimidazoles, pyrimidines, ureas, Biginelli reaction, cyclocondensation

Abstract

By cyclocondensation of 2-acylmethyl-1H-benzimidazoles with aromatic aldehydes and urea according to the Biginelli reaction, we have obtained previously unknown 6-substituted 4-aryl-5-(2-benzimidazolyl)-2-oxo-1,2,3,4-tetrahydropyrimidines. We have developed an efficient procedure for conducting the three-component reaction at fairly low temperatures. We have analyzed the structural features of the synthesized compounds based on 1H NMR spectra and IR spectroscopy.

How to Cite
Dzvinchuk, I. B.; Makitruk, T. V.; Lozinskii, M. O.  Chem. Heterocycl. Compd. 2003, 39, 455. [Khim. Geterotsikl. Soedin. 2003, 536.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1024757128442

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Published

2003-04-25

Issue

No. 4 (2003)

Section

Original Papers