SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME TRIFLUOROMETHYL DERIVATIVES OF 5-<i>tert</i>-BUTYL-2-FURYLMETHYLIDENEANILINES AND THEIR SILYL ANALOGS

Abstract

We have synthesized the corresponding aldimines by condensation of 5-tert-butylfurfural and its trimethyl- and triethylsilyl analogs with 2-, 3-, and 4-trifluoromethylanilines in the presence of 4A molecular sieves. We have studied their neurotropic and antitumor activity. The phenamine motor activity test showed that tert-butyl derivatives exhibit high efficacy and also shorten the ethanol narcosis time. Some silyl derivatives exhibit significant anti-corazole activity. The tert-butyl derivatives have high cytotoxicity toward human lung fibrosarcoma cells (the 3-trifluoromethyl-substituted derivative) and mouse hepatoma cells (the 2-trifluoromethyl-substituted derivative).

How to Cite
Iovel, I.; Golomba, L.; Zvejniece, L.; Shestakova, I.; Lukevics, E. Chem. Heterocycl. Compd. 2003, 39, 449. [Khim. Geterotsikl. Soedin. 2003, 530.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1024705111603