REACTION OF ACETONE CYANOHYDRIN WITH THIOSEMICARBAZIDE

Authors

  • Д. В. Крыльский Voronezh State University, Voronezh 394693
  • Х. С. Шихалиев Voronezh State University, Voronezh 394693
  • В. В. Пигарев Voronezh State University, Voronezh 394693
  • А. С. Соловьев Voronezh State University, Voronezh 394693

Keywords:

acetone cyanohydrin, 1,3,4-thiadizin-6-one, thiosemicarbazide, 1,2,4-triazin-5-one

Abstract

We have established that when acetone cyanohydrin is heated with thiosemicarbazide in aqueous medium, 3-mercapto-6,6-dimethyl-1,2,4-triazin-5-one and 2-methyl-2-thiosemicarbazidopropanoic acid are formed. Cyclization of the latter in dioxane in the presence of H3BO3 leads to 2-amino-5,5-dimethyl-1,3,4-thiadiazin-6-one.

How to Cite
Kryl'sky, D. V.; Shikhaliev, Kh. S.; Pigarev, V. V.; Solovyev, A. S. Chem. Heterocycl. Compd. 2002, 38, 992. [Khim. Geterotsikl. Soedin. 2002, 1133.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1020985917006

Downloads

Published

2002-08-25

Issue

No. 8 (2002)

Section

Original Papers