SYNTHESIS AND CYTOTOXICITY OF 3-(HETARYLTHIO)-1-PROPYNYL(TRIMETHYL)SILANES

Authors

  • Р. Абеле Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Абеле Latvian Institute of Organic Synthesis, Riga LV-1006
  • К. Рубина Latvian Institute of Organic Synthesis, Riga LV-1006
  • О. Дзенитис Latvian Institute of Organic Synthesis, Riga LV-1006
  • П. Арсенян Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • А. Нестерова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Домрачева Latvian Institute of Organic Synthesis, Riga LV-1006
  • Ю. Попелис Latvian Institute of Organic Synthesis, Riga LV-1006
  • C. Гринберга Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006

Keywords:

alkynes, heteroaromatic compounds, silicon-containing compounds, phase-transfer catalysis, cytotoxicity

Abstract

We have developed a two-step method for synthesis of 3-(hetarylthio)-1-propynyl(trimethyl)silanes from thiols in a phase-transfer catalysis system HC≡CCH2Br–solid K2CO3–18-crown-6-toluene followed by reaction with n-BuLi–Me3SiCl in ether or THF. We have observed that 3-[1,3-bis(trimethylsilyl)-2-propynyl]thioindole displays high cytotoxicity in HT-1080 and MG-22A tumor cell lines.

How to Cite
Abele, R.; Abele, E.; Rubina, K.; Dzenitis, O.; Arsenyan, P.; Shestakova, I.; Nesterova, A.; Domracheva, I.; Popelis, J.; Grinberga, S.; Lukevics, E. Chem. Heterocycl. Compd. 2002, 38, 867. [Khim. Geterotsikl. Soedin. 2002, 977.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1020650224525

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Published

2002-07-25

Issue

No. 7 (2002)

Section

Original Papers