SYNTHESIS AND TUBERCULOSTATIC ACTIVITY OF METHYL 3-ISONICOTINOYLDITHIOCARBAZATE AND S,S'-DIMETHYL DITHIOCARBONATE ISONICOTINOYLHYDRAZONE, AND THEIR REACTIONS WITH AMINES AND HYDRAZINES

Authors

  • H. Foks Department of Organic Chemistry Medical University of Gdańsk 80-416 Gdańsk
  • J. Mieczkowska Department of Organic Chemistry Medical University of Gdańsk 80-416 Gdańsk
  • M. Janowiec Department of Microbiology, Institute of Tuberculosis Pulmonary Diseases 01-138 Warszawa
  • Z. Zwolska Department of Microbiology, Institute of Tuberculosis Pulmonary Diseases 01-138 Warszawa
  • Z. Andrzejczyk Department of Microbiology, Institute of Tuberculosis Pulmonary Diseases 01-138 Warszawa

Keywords:

1,3-diazacycloalkanes, 1,2-diaziridine, S,S'-dimethyl dithiocarbonates, 1,3-dithiolane, isonicotinhydrazide, S-methyl dithiocarbazates, 1,2,4-triazoles, tuberculostatic activity

Abstract

Methyl 3-isonicotinoyldithiocarbazates and S,S'-dimethyl dithiocarbonate isonicotinoylhydrazone were prepared. Their reactions with primary and secondary amines, diamines, and hydrazines were studied. The newly obtained derivatives did not show tuberculostatic activity in vitro.

How to Cite
Foks, H.; Mieczkowska, J.; Janowiec, M.; Zwolska, Z.; Andrzejczyk, Z. Chem. Heterocycl. Compd. 2002, 38, 810. [Khim. Geterotsikl. Soedin. 2002, 918.]

For this article in the English edition, see DOI https://doi.org/10.1023/A:1020681604052

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Published

2002-07-25

Issue

No. 7 (2002)

Section

Original Papers