Investigations in the imidazole series 97. Synthesis and some transformations of 5-nitro-5-hydroxyalkylamino- and 4-hydroxyalkylamino-5-nitroimidazoles

Authors

  • П. М. Кочергин Zaporozh'e State Medical University, Zaporozh'e 33074
  • Л. А. Резниченко Center of the Chemistry of Medicinal Agents, All-Russia Scientific-Research Chemical-Pharmaceutical Institute, Moscow 119815
  • P. Н. Гиpева Novokuznetsk Scientific-Research Chemical-Pharmaceutical Institute, Novokuznets 654034
  • E. B. Александрова Zaporozh'e State Medical University, Zaporozh'e 33074

Abstract

A series of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-hydroxyalkylamino- and 4-hydroxyalkylamino-5-nitro-imidazoles were obtained by the reaction of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-chloro(bromo)imidazoles with amino alcohols. Their reactions with thionyl chloride and carboxylic acid halides and their catalytic hydrogenation were studied.

How to Cite
Kochergin, P. M.; Reznichenko, L. A.; Gireva, R. N.; Aleksandrova, E. V. Chem. Heterocycl. Compd. 1998, 34, 1142. [Khim. Geterotsikl. Soedin. 1998, 34, 1346.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02319492

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Published

1998-10-25

Issue

No. 10 (1998)

Section

Original Papers