Cyclization of N-allylthiourea derivatives by the action of α-chloronitrosoalkanes

Authors

  • C. E. Ткаченко Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka 142432
  • А. H. Пушин Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka 142432
  • B. Б. Соколов Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka 142432
  • B. M. Федосеев Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka 142432
  • И. B. Мартынов Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka 142432

Abstract

A convenient method is proposed for obtaining difficultly available derivatives of 2-amino-5-chloromethyl-2-thiazoline by the cyclization of N-allythioureas under the action ofα-chloronitrosoalkanes. It is assumed that the reaction proceeds as a halogenophilic process leading to the intermediate formamidinesulfenyl chloride which is rapidly and selectively cyclized with the formation of 2-amino-2-thiazoline derivatives.

How to Cite
Tkachenko, S. E.; Pushin, A. N.; Sokolov, V. B.; Fedoseev, V. M.; Martynov, I. V. Chem. Heterocycl. Compd. 1998, 34, 347. [Khim. Geterotsikl. Soedin. 1998, 34, 381.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02290730

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Published

1998-03-25

Issue

No. 3 (1998)

Section

Original Papers