Synthesis and reactions of 2-(4-pyridyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinazoline

Abstract

7,7-Dimethyl- and 7-phenyl-2-(4-pyridyl)-5-oxo-5,6,7,8-tetrahydroquinazolines were synthesized in the reactions of 2-formyl-5,5-dimethyl- and 5-phenyl-1,3-cyclohexanediones, respectively, with 4-amidinopyridine. The oxime, thiosemicarbazone, 4-quinazolyl-, nicotinoyl-, isonicotinoyl-, and 2-hydroxybenzoylhydrazones of 2-(4-pyridyl)-5-oxo-7,7-dimethyl-5,6,7,8-tetrahydroquinazoline were obtained. The reduction of this ketone by sodium borohydride leads to the 5-hydroxy derivative.

How to Cite
Tonkikh, N. N.; Strakov, A. Y.; Petrova, M. V. Chem. Heterocycl. Compd. 1998, 34, 92. [Khim. Geterotsikl. Soedin. 1998, 34, 101.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02290618