Utilization of the amidoalkylation reaction in the synthesis of hydrogenated pyrimidine-2-thiones

Abstract

Reaction of thiourea, propionic aldehyde, or benzaldehyde and p-toluenesulfinic acid gave α-substituted N-(tosylmethyl)thioureas. Interaction of the last with sodioacetoacetic ester or sodiobenzoylacetic ester led to the synthesis of the corresponding 4-hydroxy-5-ethoxycarbonylhexahydropyrimidine-2-thiones, the dehydration of which afforded 5-ethoxycarbonyl-1,2,3,4-tetrahydropyrimidine-2-thiones.

How to Cite
Shutalev, A. D.; Kuksa, V. A. Chem. Heterocycl. Compd. 1997, 33, 91. [Khim. Geterotsikl. Soedin. 1997, 105.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF02290753