Amidoalkylation of 2- and 4-hydroxy-pyrimidines with N-(1,2,2,2-tetrachloroethyl)amides of carboxylic acids

Authors

  • Л. П. Приказчикова Institute of Bioorganic Chemistry and Petroleum Chemistry, National Academy of Sciences of Ukraine, 253660, Kiev
  • Л. И. Рыбченко Institute of Bioorganic Chemistry and Petroleum Chemistry, National Academy of Sciences of Ukraine, 253660, Kiev
  • С. B. Ключко Institute of Bioorganic Chemistry and Petroleum Chemistry, National Academy of Sciences of Ukraine, 253660, Kiev
  • В. B. Пироженко Institute of Bioorganic Chemistry and Petroleum Chemistry, National Academy of Sciences of Ukraine, 253660, Kiev
  • Б. C. Драч Institute of Bioorganic Chemistry and Petroleum Chemistry, National Academy of Sciences of Ukraine, 253660, Kiev

Abstract

The reaction of 2- and 4-hydroxypyrimidines with N-(1,2,2,2-tetrachloroethyl)amides of carboxylic acids in the presence of sodium hydroxide or triethylamine leads to products of amidoalkylation at the N(1) and N(3) atoms respectively. In addition, 2-alkyl-4-hydroxy-pyrimidines give products of O- or C-amidoalkylation with the reagents indicated, evidently caused by steric factors and by kinetic and thermodynamic control.

How to Cite
Prikazchikova, L. P.; Rybchenko, L. I.; Klyuchko, S. V.; Pirozhenko, V. V.; Drach, B. S.  Chem. Heterocycl. Compd. 1994, 30, 1235. [Khim. Geterotsikl. Soedin. 1994, 1424.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01184892

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Published

1994-10-25

Issue

No. 10 (1994)

Section

Original Papers