Conversions of polyfunctional 3-amino-1(2H)isoquinolines

Authors

  • Ю. М. Воловeнко Taras Shevchenko Kiev University, Kiev 252601
  • T. А. Волoвненко Taras Shevchenko Kiev University, Kiev 252601
  • Ф. C. Бабичев Taras Shevchenko Kiev University, Kiev 252601

Abstract

The acylation of 3-amino-4-cyano-1(2H)isoquinolines with benzoyl chloride leading to the formation of 1,3-oxazino[4,5-c]isoquinoline-6-ones has been studied. Previously undescribed 1-aminopyrimido[4,5-c]isoquinolin-6-ones have been obtained by the reaction of the appopriate 3-amino-1(2H)isoginolones with formamide. Nucleophilic replacement has been carried out with 3-amino-1-chloroisoquinoline by the action of sodium hydroxide, primary alcohols, hydrazine hydrate, and various amines. 1,2,4-Triazino[2,3-b]isoquinolone has been synthesized by condensing 2,3-diamino-1(2H)isoquinolone with mesoxalic acid ethyl ester.

How to Cite
Volovenko, Yu. M.; Volovnenko, T. A.; Babichev, F. S. Chem. Heterocycl. Compd. 1994, 30, 453. [Khim. Geterotsikl. Soedin. 1994, 515.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01169941

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Published

1994-04-25

Issue

No. 4 (1994)

Section

Original Papers