SYNTHESIS AND MOLECULAR STRUCTURE STUDY OF 3-METHOXY-7α-METHYL-6-OXA-9β,14β-ESTRA-1,3,5(10)-TRIEN-17-ONE IN SOLUTION

Authors

  • С. И. Селиванов St. Petersburg State University
  • С. Н. Морозкина St. Petersburg State University
  • А. Г. Шавва St. Petersburg State University

DOI:

https://doi.org/10.1007/1187

Keywords:

9β, 14β-analogs of steroidal estrogens, antiradical activity, DFQ-COSY method of NMR spectroscopy, J-COSY method of NMR spectroscopy, HSQCnd method of NMR spectroscopy, NOESY method of NMR spectroscopy, steroidal estrogen structure determination, uterotropic activity

Abstract

It was established by NMR spectroscopy that the catalytic hydrogenation of 3-methoxy-7α-methyl-6-oxa-14β-estra-1,3,5(10),8-tetraen-17-one leads to the formation of 3-methoxy-7α-methyl-6-oxa-9β,14β-estra-1,3,5(10)-trien-17-one, the structure of which was investigated in solution. The corresponding analog with a free hydroxyl group at the position 3 possesses an antiradical activity at the absence of uterotropic effect.

Authors: S. I. Selivanov, S. N. Morozkina, and A. G. Shavva.

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (5), pp 704-714

http://link.springer.com/article/10.1007/s10593-012-1048-5

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Published

2013-11-20

Issue

No. 5 (2012)

Section

Original Papers