DIRECTION OF 3-BROMOTHIOPHENE ACYLATION WITH SUCCINYL CHLORIDE
DOI:
https://doi.org/10.1007/459Keywords:
3-bromothiophene, dibromo-1, 4-di(2-thienyl)butane-1, 4-diones, succinyl chloride, thiophene, acylationAbstract
In the reaction of 3-bromothiophene with succinyl chloride in the presence of AlCl3, a mixture of three isomeric dibromo-substituted 1,4-di(2-thienyl)butane-1,4-diones was formed. The main component was the unsymmetrical 1-(3-bromo-2-thienyl)-4-(4-bromo-2-thienyl)butane-1,4-dione rather than 1,4-di(3-bromo-2-thienyl)butane-1,4-dione expected according to the orientation rules.
Authors: V. I. Smirnov, A. V. Afanas'ev, I. S. Prostakishin, and L. I. Belen'kii
English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (3), pp 386-391