DIRECTION OF 3-BROMOTHIOPHENE ACYLATION WITH SUCCINYL CHLORIDE

Abstract

In the reaction of 3-bromothiophene with succinyl chloride in the presence of AlCl₃, a mixture of three isomeric dibromo-substituted 1,4-di(2-thienyl)butane-1,4-diones was formed. The main component was the unsymmetrical 1-(3-bromo-2-thienyl)-4-(4-bromo-2-thienyl)butane-1,4-dione rather than 1,4-di(3-bromo-2-thienyl)butane-1,4-dione expected according to the orientation rules.

Authors: V. I. Smirnov, A. V. Afanas'ev, I. S. Prostakishin, and L. I. Belen'kii

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (3), pp 386-391

http://link.springer.com/article/10.1007/s10593-013-1258-5