SYNTHESIS AND BIOACTIVITY OF NOVEL (γ-PIPERIDONO)DIBENZO-33-AZA-14-CROWN-3 ETHERS

Authors

  • Thi Nhung Dao Faculty of Chemistry, VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi 100000
  • Hong Hieu Truong RUDN University, 6 Miklukho-Maklaya St., Moscow 117198
  • Van Boi Luu Faculty of Chemistry, VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi 100000
  • Anatoly T. Soldatenkov RUDN University, 6 Miklukho-Maklaya St., Moscow 117198
  • Nadezhda M. Kolyadina RUDN University, 6 Miklukho-Maklaya St., Moscow 117198
  • Alena N. Kulakova National Research Center ''Kurchatov Institute'', 1 Akademika Kurchatova Sq., Moscow 123182
  • Victor N. Khrustalev RUDN University, 6 Miklukho-Maklaya St., Moscow 117198 National Research Center ''Kurchatov Institute'', 1 Akademika Kurchatova Sq., Moscow 123182
  • Ayalev T. Wodajo College of Natural and Computational Sciences, Department of Chemistry, University of Gondar, P. O. Box 196, Gondar
  • Hong Quan Nguyen Faculty of Chemistry, VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi 100000
  • Thi Tan Van Tran Faculty of Chemistry, VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi 100000
  • Tuan Anh Le Faculty of Chemistry, VNU University of Science, 19 Le Thanh Tong, Hoan Kiem, Hanoi 100000

DOI:

https://doi.org/10.1007/4986

Keywords:

azacrown ether, 2, 2'-[oxybis(ethane-2, 1-diyloxy)]dinaphthalene-1-carbaldehyde, Petrenko–Kritschenko reaction, cytotoxicity, X-ray diffraction study

Abstract

Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity against Hep-G2, Lu1, RD, and MCF-7 cell lines. In addition, three of the synthesized azacrown ethers showed positive effect in antimicrobial test against Aspergillus niger.

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Published

2019-07-23

Issue

Vol. 55 No. 7 (2019)

Section

Original Papers