SYNTHESIS AND BIOACTIVITY OF NOVEL (γ-PIPERIDONO)DIBENZO-33-AZA-14-CROWN-3 ETHERS
DOI:
https://doi.org/10.1007/4986Ключевые слова:
azacrown ether, 2, 2'-[oxybis(ethane-2, 1-diyloxy)]dinaphthalene-1-carbaldehyde, Petrenko–Kritschenko reaction, cytotoxicity, X-ray diffraction studyАннотация
Three-component reaction of polyether-linked bisnaphthaldehyde, ketone derivative, and ammonium acetate afforded seven new azacrown ethers containing γ-piperidone fragment with moderate yields. Most of the compounds were tested for their bioactivity. (3,5-Diethylpiperidono)azacrown ether showed significant cytotoxicity against Hep-G2, Lu1, RD, and MCF-7 cell lines. In addition, three of the synthesized azacrown ethers showed positive effect in antimicrobial test against Aspergillus niger.
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Опубликован
2019-07-23
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Оригинальные статьи