SYNTHESIS OF NOVEL UNSYMMETRICALLY SUBSTITUTED 1,4-DIHYDROISONICOTINIC ACID AND ITS DERIVATIVES

Authors

  • I. Goba Latvian Institute of Organic Synthesis
  • B. Turovska Latvian Institute of Organic Synthesis
  • S. Belyakov Latvian Institute of Organic Synthesis

DOI:

https://doi.org/10.1007/5

Keywords:

1, 4-dihydropyridines, unsymmetrical 1, 4-dihydroisonicotinic acid, alkylation, esterification

Abstract

The synthesis of new unsymmetrically substituted 1,4-dihydroisonicotinic acid bearing cyano and acetyl groups in positions 3 and 5 of the heterocycle has been developed. The methyl, ethoxycarbonylmethyl, and propionyloxymethyl esters of the acid have been obtained. The method of N-alkylation reaction of synthesized 1,4-dihydroisonicotinic acid esters has been elaborated.

Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (5), pp 726-735

http://link.springer.com/article/10.1007/s10593-013-1304-3

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Published

2013-05-10

Issue

No. 5 (2013)

Section

Original Papers