SYNTHESIS OF NOVEL UNSYMMETRICALLY SUBSTITUTED 1,4-DIHYDROISONICOTINIC ACID AND ITS DERIVATIVES
DOI:
https://doi.org/10.1007/5Ключевые слова:
1, 4-dihydropyridines, unsymmetrical 1, 4-dihydroisonicotinic acid, alkylation, esterificationАннотация
The synthesis of new unsymmetrically substituted 1,4-dihydroisonicotinic acid bearing cyano and acetyl groups in positions 3 and 5 of the heterocycle has been developed. The methyl, ethoxycarbonylmethyl, and propionyloxymethyl esters of the acid have been obtained. The method of N-alkylation reaction of synthesized 1,4-dihydroisonicotinic acid esters has been elaborated.
Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (5), pp 726-735
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Опубликован
2013-05-10
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Оригинальные статьи