PHOTOREGULATED MACROCYCLIC CELL-PENETRATING PEPTIDES

Authors

  • Igor V. Komarov Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv 01601, Ukraine
  • Iuliia V. Bakanovych Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv 01601, Ukraine

DOI:

https://doi.org/10.1007/5692

Keywords:

macrocycles, cell-penetrating peptides, photoswitches, diarylethenes, azobenzenes, photopharmacology

Abstract

Light-controlled cell-penetrating peptides are reviewed as emerging photopharmacology tools. Key discoveries made recently in this area demonstrated that photoregulation of the cell-penetrating ability is very efficient in structural contexts of (macro)heterocyclic peptidic molecules, containing azobenzene or diarylethene photoisomerizable moieties.

Author Biography

Igor V. Komarov, Enamine Ltd., 78 Chervonotkatska St., Kyiv 02094, Ukraine Taras Shevchenko National University of Kyiv, 60 Volodymyrska St., Kyiv 01601, Ukraine

Head of Supramolecular Chemistry Chair

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Published

2020-07-10

Issue

Vol. 56 No. 6 (2020): Heterocyclic сompounds in medicinal chemistry

Section

Heterocycles in Focus