SILVER-ASSISTED PALLADIUM-CATALYZED ONE-POT SYNTHESIS OF 3-(HETERO)ARYLMETHYL DERIVATIVES OF IMIDAZO[1,2-<i>a</i>]PYRIDINES

Authors

  • Krishna C. Kasina Discovery Chemistry Solutions, GVK Biosciences, Nacharam, Hyderabad, Telangana State, 500076, India Department of Inorganic and Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India
  • Siva K. Rapeti Discovery Chemistry Solutions, GVK Biosciences, Nacharam, Hyderabad, Telangana State, 500076, India
  • Arghya Sadhukhan Discovery Chemistry Solutions, GVK Biosciences, Nacharam, Hyderabad, Telangana State, 500076, India
  • Mahesh Ranga Discovery Chemistry Solutions, GVK Biosciences, Nacharam, Hyderabad, Telangana State, 500076, India
  • Arani Pal Discovery Chemistry Solutions, GVK Biosciences, Nacharam, Hyderabad, Telangana State, 500076, India
  • Saritha Birudaraju Discovery Chemistry Solutions, GVK Biosciences, Nacharam, Hyderabad, Telangana State, 500076, India
  • Siva r. Tirukkovalluri Department of Inorganic and Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India

DOI:

https://doi.org/10.1007/5864

Keywords:

benzylimidazo[1, 2-a]pyridine, C–C coupling, 5-exo-dig cyclization, metal-catalyzed reactions, one-pot synthesis.

Abstract

3-(Hetero)arylmethyl derivatives of imidazo[1,2-a]pyridine have been synthesized by a novel one-pot method consisting of the Sonogashira coupling of tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate with different substituted (hetero)aryl bromides and cyclization of the in situ obtained intermediate substituted (hetero)aryl acetylene derivatives.

Author Biography

Siva r. Tirukkovalluri, Department of Inorganic and Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India

Department of Inorganic and Analytical Chemistry, Andhra University.

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Published

2021-05-26

Issue

Vol. 57 No. 5 (2021)

Section

Original Papers