BENZAZOLES. 6. SYNTHESIS AND ARYLSULFONATION OF 2-HYDROXYMETHYLBENZIMIDAZOLE
DOI:
https://doi.org/10.1007/619Keywords:
1-arylsulfonyl-2-hydroxymethylbenzimidazoles, 1-arylsulfonyl-2-chloromethylbenzimid-azoles, 2-hydroxymethylbenzimidazole, arylsulfonylation, nucleophilic substitutionAbstract
2-Hydroxymethylbenzimidazole was synthesized by the cyclization of o-phenylenediamine with glycolic acid. Its interaction with arylsulfonyl chlorides in the presence of triethylamine showed that in addition to the expected 1-arylsulfonyl-2-hydroxymethylbenzimidazoles, the formation of 1-arylsulfonyl-2-chloromethylbenzimidazoles was observed. It turned out that an increase in the quantity of arylsulfonyl chlorides was capable of increasing the fraction of 1-arylsulfonyl-2-chloromethylbenzimidazoles.
Authors: K. B. Abdireimov, N. S. Mukhamedov, R. Ya. Okmanov, M. Zh. Aiymbetov, B. Tashkhodzhaev, and Kh. M. Shakhidoyatov.
English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (5), pp 760-765