BENZAZOLES. 6. SYNTHESIS AND ARYLSULFONATION OF 2-HYDROXYMETHYLBENZIMIDAZOLE

Authors

  • К. Б. Абдиреймов S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan
  • Н. С. Мухамедов S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan
  • Р. Я. Окманов S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan
  • М. Ж. Айымбетов S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan
  • Б. Ташходжаев S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan
  • Х. М. Шахидоятов S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan

DOI:

https://doi.org/10.1007/619

Keywords:

1-arylsulfonyl-2-hydroxymethylbenzimidazoles, 1-arylsulfonyl-2-chloromethylbenzimid-azoles, 2-hydroxymethylbenzimidazole, arylsulfonylation, nucleophilic substitution

Abstract

2-Hydroxymethylbenzimidazole was synthesized by the cyclization of o-phenylenediamine with glycolic acid. Its interaction with arylsulfonyl chlorides in the presence of triethylamine showed that in addition to the expected 1-arylsulfonyl-2-hydroxymethylbenzimidazoles, the formation of 1-arylsulfonyl-2-chloromethylbenzimidazoles was observed. It turned out that an increase in the quantity of arylsulfonyl chlorides was capable of increasing the fraction of 1-arylsulfonyl-2-chloromethylbenzimidazoles.

Authors: K. B. Abdireimov, N. S. Mukhamedov, R. Ya. Okmanov, M. Zh. Aiymbetov, B. Tashkhodzhaev, and Kh. M. Shakhidoyatov.

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (5), pp 760-765

http://link.springer.com/article/10.1007/s10593-013-1307-0

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Published

2013-05-17

Issue

No. 5 (2013)

Section

Original Papers