CONDENSED ISOQUINOLINES. 33. SYNTHESIS OF 1'-R-SPIRO[7H,8H-2a,7a-DIAZACYCLOPENTA[<i>fg</i>]NAPHTHACENE-2,4'-(1'H)-PYRIDINE]-1,8(2H)-DIONES

Authors

  • Л. М. Потиха Taras Shevchenko National University, Kiev 01033
  • Р. М. Гуцул Taras Shevchenko National University, Kiev 01033
  • В. А. Ковтуненко Taras Shevchenko National University, Kiev 01033

DOI:

https://doi.org/10.1007/6877

Keywords:

2a, 7a-diazacyclopenta[fg]naphthacene, enamines, isoquino[3, 2-b]quinazoline, spiro-1, 4-dihydropyridine, alkylation, acylation

Abstract

Heating 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one with isonicotinoyl chloride in pyridine gives 6-isonicotinoyl-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one. The 1-alkyl-4[(11-oxo-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-6-yl)carbonyl]pyridinium iodides obtained by alkylation of 6-isonicotinoyl-5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one using alkyl iodides in the presence of NaH are converted to 1'-R-spiro[7H,8H-2a,7a-diazacyclopenta[fg]naphthacene-2,4'(1'H)-pyridine]-1,8(2H)-diones. The chemical and spectroscopic properties of the spiro compounds obtained were studied.

How to Cite
Potikha, L. M.; Gutsul, R. M.; Kovtunenko, V. A.  Chem. Heterocycl. Compd. 2009, 45, 42. [Khim. Geterotsikl. Soedin. 2009, 52.]

For this article in the English edition see DOI 10.1007/s10593-009-0223-9

 

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Published

2022-07-06

Issue

No. 1 (2009)

Section

Original Papers