4-HYDROXY-2-QUINOLONES. 113. SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF N-R-AMIDES OF 4-HYDROXY-6-METHYL-2-OXO-1-PROPYL-1,2,5,6,7,8-HEXAHYDROQUINOLINE-3-CARBOXYLIC ACID

Authors

  • И. В. Украинец National Pharmaceutical University, Kharkiv 61002
  • Е. В. Колесник National Pharmaceutical University, Kharkiv 61002
  • Л. В. Сидоренко National Pharmaceutical University, Kharkiv 61002
  • О. В. Горохова National Pharmaceutical University, Kharkiv 61002
  • А. В. Туров Kiev Taras Shevchenko National University, Kiev 01033

DOI:

https://doi.org/10.1007/7644

Keywords:

amides, 4-hydroxy-2-oxoquinoline-3-carboxylic acids, antitubercular activity, X-ray structural analysis, thermolysis

Abstract

A preparative method has been developed and the synthesis has been effected of anilides and heterylamides of 4-hydroxy-6-methyl-2-oxo-1-propyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid. A comparative analysis has been carried out of  the structure and antitubercular properties of the synthesized compounds and their analogs unsubstituted in the quinoline nucleus.

How to Cite
Ukrainets, I. V.; Kolesnik, E. V.; Sidorenko, L. V.; Gorokhova, O. V.; Turov, A. V.  Chem. Heterocycl. Compd. 2007, 43, 326. [Khim. Geterotsikl. Soedin. 2007, 405.]

For this article in the English edition see DOI 10.1007/s10593-007-0049-2


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Published

2023-03-30

Issue

No. 3 (2007)

Section

Original Papers