SYNTHESIS OF CYTOTOXIC DERIVATIVES OF 2-OXO-1-AZETIDINYLACETAMIDE

Authors

  • Г. Вейнберг Latvian Institute of Organic Synthesis, Riga LV-1006
  • К. Диковская Latvian Institute of Organic Synthesis, Riga LV-1006
  • М. Ворона Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Туровский Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Шестакова Latvian Institute of Organic Synthesis, Riga LV-1006
  • И. Канепе Latvian Institute of Organic Synthesis, Riga LV-1006
  • Э. Лукевиц Latvian Institute of Organic Synthesis, Riga LV-1006

DOI:

https://doi.org/10.1007/8408

Keywords:

N-cyclohexyl-α-(4-benzyloxycarbonyl-2-oxo-1-azetidinyl)-α-(aryl)acetamides, N-cyclohexyl-α-(2-oxo-4-phenyl-1-azetidinyl)-α-(aryl)acetamides, N-cyclohexyl-α-(3-benzyloxycarbonylamino-2-oxo-1-azetidinyl)-α-(4-cyanophenyl)acetamide, N-cyclohexyl-α-(3-tert-butoxycarbonylamino-2-oxo-1-azetidinyl)-α-(aryl)acetamides, N-tolylsulfonyl-α-(2-chloro-4-nitrophenyl)-α-(2-oxo-1-azetidinyl)acetamide, cytotoxic activity

Abstract

New derivatives of 2-oxo-1-azetidinylacetamide have been synthesized by the four-component condensation of  β-amino acids with aldehydes and isonitriles. Study of their cytotoxic activity in vitro revealed a cytotoxic effect of individual compounds in relation to cancer cells of human fibrosarcoma, mouse hepatoma, and mouse neuroblastoma.

How to Cite
Veinberg, G.; Dikovskaya, K.; Vorona, M.; Turovskis, I.; Shestakova, I.; Kanepe, I.; Lukevics; E.  Chem. Heterocycl. Compd. 2005, 41, 93. [Khim. Geterotsikl. Soedin. 2005, 107.]

For this article in the English edition, see DOI 10.1007/s10593-005-0113-8

 

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Published

2023-12-05

Issue

No. 1 (2005)

Section

Original Papers