TWO DIRECTIONS OF THE REACTION OF 4-BROMOBENZALDEHYDE WITH SUBSTITUTED ACETOPHENONES AND UREA. SYNTHESIS OF ARYL-SUBSTITUTED PYRIMIDIN-2-ONE AND HEXAHYDROPYRIMIDO[4,5-<i>d</i>]PYRIMIDIN-2,7-DIONE

Authors

  • В. Ф. Седова N. N. Vorozhstsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090
  • О. П. Шкурко N. N. Vorozhstsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090

Keywords:

4-alkylacetophenones, aminopyrimidines, 4-bromoacetaldehyde, 5-bromo-1H-pyrimidin-2-ones, hexahydro-1H,8H-pyrimido[4,5-d]pyrimidin-2,7-diones, 4,6-diaryl-1H-pyrimidin-2-ones, chloropyrimidines, bromination, condensation

Abstract

Condensation of 4-bromobenzaldehyde, urea, and 4-alkyl-substituted acetophenones gave substituted hexahydro-1H,8H-pyrimido[4,5-d]pyrimidin-2,7-diones or 1H-pyrimidin-2-ones, depending on the substituent on the acetophenone ring and the nature of the solvent (i-PrOH, BuOH, AcOH). The corresponding 5-bromopyrimidin-2-ones were formed on bromination of these compounds. The structures of these compounds were confirmed by IR, UV, and 1H NMR spectroscopy.

How to Cite
Sedova, V. F.; Shkurko, O. P. Chem. Heterocycl. Compd. 2004, 40, 194. [Khim. Geterotsikl. Soedin. 2004, 229.]

For this article in the English edition, see DOI 10.1023/B:COHC.0000027891.72906.c7

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Published

2004-02-25

Issue

No. 2 (2004)

Section

Original Papers