SYNTHESIS OF SUBSTITUTED 3-AMINOSPIRO-4-BUT-2-ENOLIDES

Abstract

Previously unknown 3-N-alkylamino-, 3-N,N-dialkylamino-4-but-2-enolides containing spirocyclic moiety have been synthesized by nucleophilic addition of amines at the triple bond of methyl ester of β-(1-hydroxycyclohexyl)propiolic acid or by the reaction of amines with the corresponding 3-methoxy-4-but-2-enolide.

Authors: M. V. Mavrov and N. I. Simirskaya.

English Translation in Chemistry of Heterocyclic Compounds, 1999, 35 (10), pp 1150-1155

http://link.springer.com/article/10.1007/BF02323371