PREPARATION OF 6-UNSUBSTITUTED 3,4-DIHYDROPIRIMIDIN-2(1<i>Н</i>)-ONES AND 2-ARYLAMINOPYRIMIDINES

Authors

  • С. Терентьева Latvian Institute of Organic Syntheses
  • Д. Муцениеце Институт органического синтеза
  • В. Лусис Институт органического синтеза

DOI:

https://doi.org/10.1007/1060

Keywords:

2-oxo-1, 2, 3, 4-tetrahydropyrimidines, 2-dihydropyrimidines, 2-chloropyrimidines, 2-(arylamino)pyrimidines, Biginelli reaction

Abstract

A series of new 6-unsubstituted 3,4-dihydropyrimidin-2(1H)-ones have been obtained from methyl propiolate, as well as from methyl 3-diethylaminoacrylate, using the Biginelli reaction. By subsequent oxidation of the pyrimidine reing, clorination of the 2-oxo group, and substitution of the chlorine atom by an aromatic amine they have been converted into heretofore unknown 2-(arylamino)pyrimidines. 2-Oxo- and 2-(arylamino)pyrimidine-5-carboxylic acids also were obtained.

How to Cite
Terentjeva, S.; Muceniece, D.; Lusis, V. Chem. Heterocycl. Compd. 2014, 49, 1757. [Khim. Geterotsikl. Soedin. 2013, 1896.]

For this article in the English edition see DOI 10.1007/s10593-014-1428-0

Author Biographies

С. Терентьева, Latvian Institute of Organic Syntheses

Светлана Терентьева

Д. Муцениеце, Институт органического синтеза

Дзинтра Муцениеце

В. Лусис, Институт органического синтеза

Виестурс Лусис

Published

2013-12-17

Issue

Section

Original Papers