Synthesis of substituted 5-aminothieno[2,3-<i>d</i>]pyrimidines

Abstract

The corresponding N,N-dimethyl-N′-(thieno[2,3-d]pyrimidin-5-yl)formamidines and 5-acylaminothieno[2,3-d]pyrimidines have been synthesized by the reaction of ethyl 5-amino-2-substituted thieno[2, 3-d]pyrimidine-6-carboxylates with (a) either the dimethylacetal of dimethylformamide or chloroacetyl chloride or (b) ethoxycarbonylacetyl chloride or acetic anhydride. Heating ethyl 5-amino-2-methylthiothieno[2,3-d]pyrimidine-6-carboxylate with allyl isothiocyanate in pyridine gave 3-allyl-2-allylthio-7-methylthiotlzieno[2,3-d:4,5d′]pyrimidin-4(3H)-one.

How to Cite
Tumkyavichius, S. Chem. Heterocycl. Compd. 1995, 31, 859. [Khim. Geterotsikl. Soedin. 1995, 986.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01170749