Condensed isoquinoline. 5. Reaction of the 6-methyl-5-oxoisoquino[2,3-<i>a</i>]quinazolinium cation with certain nucleophiles

Authors

  • B. М. Кисиль Taras Shevchenko Kiev University, Kiev 252601
  • B. А. Ковтуненко Taras Shevchenko Kiev University, Kiev 252601
  • Л. М. Потиха Taras Shevchenko Kiev University, Kiev 252601
  • А. B. Туров Taras Shevchenko Kiev University, Kiev 252601

Abstract

It has been shown that nucleophilic reagents react with the 6-methyl-5-oxoisoquino[2,3-a]quinazolinium cation at the C(2) atom. The structure of the reaction product is determined by the type of reagent. On reaction with sodium borohydride and secondary amines, 12H- and 12-dialkylamino-12H-6-methyl-5-oxo-5,6-dihydroisoquino[2,3-a]quinazolines are formed. In the case of primary amines the reaction is accompanied by fission of the C(12)-N(t3) bond with the formation of 2-[o-(N-alkylformimidoyl)benzyl]-3-methyl-4-oxoquinazolines.

How to Cite
Kisel', V. M.; Kovtunenko, V. A.; Potikha, L. M.; Turov, A. V. Chem. Heterocycl. Compd. 1995, 31, 457. [Khim. Geterotsikl. Soedin. 1995, 522.]

For this article in the English edition, see DOI https://doi.org/10.1007/BF01177018

Downloads

Published

1995-04-25

Issue

No. 4 (1995)

Section

Original Papers