SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW PHENYTOIN DERIVATIVES AND THEIR ACYCLIC NUCLEOSIDE ANALOGS

Authors

  • O. M. Ali Department of Chemistry, Faculty of Science, Menoufia University
  • H. H. Amer Department of Chemistry, Faculty of Science, Menoufia University
  • A. A. Mosaad Department of Bacteriology, Faculty of Veterinary Medicine, Menoufia University
  • A. A.-H. Abdel-Rahman Department of Chemistry, Faculty of Science, Menoufia University

DOI:

https://doi.org/10.1007/1123

Keywords:

acyclic nucleosides, phenytoin derivatives, sugar hydrazones, antimicrobial activity

Abstract

New phenytoin derivatives and their N-substituted acyclic nucleoside analogs were prepared. The synthesized compounds were tested for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Streptomyces Sp. Most of tested compounds exhibited moderate to high antimicrobial activity while few compounds were found to exhibit little or no activity against the tested microorganisms.

Also published in Chemistry of Heterocyclic Compounds, 2012, 48 (7), pp 1043-1049

http://link.springer.com/article/10.1007/s10593-012-1097-9

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Published

2013-11-05

Issue

No. 7 (2012)

Section

Original Papers