SYNTHESIS OF 1-SUBSTITUTED 5-ACETYL (ETHOXYCARBONYL)-2,3-DIHYDROPYRAZOLO[3,4-<i>b</i>]PYRIDIN-3-ONES

Authors

  • П. С. Лебедь Institute of Organic Chemistry, National Academy of Sciences of Ukraine
  • Н. Г. Мозговая Institute of Organic Chemistry, National Academy of Sciences of Ukraine
  • О. В. Манойленко Kyiv Taras Shevchenko National University
  • В. С. Толмачова M. Dragomanov National Pedagogical University
  • М. В. Вовк Institute of Organic Chemistry, National Academy of Sciences of Ukraine

DOI:

https://doi.org/10.1007/1127

Keywords:

5-acetyl-4-methyl-1, 2-dihydropyrazolo[3, 4-b]pyridin-3-ones, 1-substituted 5-aminopyrazol-3-ones, ethyl 4-hydroxy-3-oxo-2, 3-dihydropyrazolo[3, 4-b]pyridine-5-carboxylate, ethoxymethylidene-β-dicarbonyl compounds

Abstract

1-Substituted 5-aminopyrazol-3-ones react selectively with ethoxymethylidene β-dicarbonyl compounds (3-ethoxymethylidene-2,4-pentanedione, diethyl 2-ethoxymethylidenemalonate, and ethyl 2-ethoxy-methylideneacetoacetate) with the formation of dihydropyrazolylaminomethylidene β-dicarbonyl derivatives, which undergo thermal intramolecular cyclization to 5-functionalized dihydro-pyrazolo[3,4-b]pyridin-3-ones.

Authors: P. S. Lebed', N. G. Mozgovaya, O. V. Manoilenko,
V. S. Tolmachova, and M. V. Vovk.

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (7), pp 1058-1063

http://link.springer.com/article/10.1007/s10593-012-1099-7

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Published

2013-11-05

Issue

No. 7 (2012)

Section

Original Papers