SYNTHESIS OF IMIDAZO[4,5-<i>b</i>]PYRIDINES WITH A CHIRAL SUBSTITUENT AT THE NITROGEN ATOM AND THEIR CONVERSION TO PIPERAZINE DERIVATIVES
DOI:
https://doi.org/10.1007/1198Keywords:
tert-butyl imidazo[4, 5-b]pyridine-2-carboxylate, 2-chloro-3-nitropyridine, chiral substituent at a nitrogen atom, nucleophilic substitution, optically active amino acid estersAbstract
Imidazopyridine and benzimidazole derivatives have been prepared with chiral substituents at the nitrogen atom and have been converted to the corresponding condensed structures fused with a piperazine ring. A method has been developed for the synthesis of novel class of compounds – 6,7,8,9-tetrahydropyrido[3',2':4,5]imidazo[1,2-a]pyrazine derivatives.
Authors: K. V. Bukhryakov, A. V. Kurkin, and M. A. Yurovskaya.
English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (5), pp 773-784
