SYNTHESIS OF BIS-β,β'-SPIRO-PYRROLIDINYL-OXINDOLES, CONTAINING A RHODANINE FRAGMENT

Abstract

The synthesis of isatilidene derivatives of N-alkylrhodanines has been carried out with dipolarophiles and unstable azomethine ylides, generated in situ from sarcosine and paraformaldehyde. A series of chiral pyrrolidinyl-oxindoles spirofused in the β,β'-positions has been synthesized in the result of cycloaddition in high yield and diastereoselectivity.

Authors: A. A. Shvets and S. V. Kurbatov.

English Translation in Chemistry of Heterocyclic Compounds, 2012, 48 (5), pp 799-806

http://link.springer.com/article/10.1007/s10593-012-1059-2