SYNTHESIS AND CYTOTOXICITY OF PYRIDINE AND QUINOLINE OXORHENIUM(V) COMPLEXES WITH TRIDENTATE (NS₂, S₃)/MONODENTATE (S) COORDINATION

Abstract

New oxorhenium complexes with tridentate 3-thia- and 3-methylazapentane-1,5-dithiolate and monodentate pyridine and quinoline derivatives have been synthesized. As a result of investigation of biological activity a high cytotoxicity was found for the synthesized complexes in relation to tumor cells. The specificity of the 2-pyridylthiolato[3-(N-methyl)azapentane-1,5-dithiolato]oxorhenium(V) cytotoxic action towards cells of mouse hepatoma MG-22A on a background of low acute toxicity was established.

Authors: I. Segal, A. Zablotskaya, T. Kniess, and I. Shestakova.

English translation in Chemistry of Heterocyclic Compounds, 2012, 48 (2), pp 296-300

http://link.springer.com/article/10.1007/s10593-012-0989-z