SYNTHESIS OF 3-{3-[(4-METHYLCYCLOHEX-3-ENYLCARBONYL)AMINO]-4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL}PROPANOIC ACID ANILIDES

Abstract

With the aim of discovering potential diuretic agents amongst quinazoline anilides we have prepared anilides of 3-{3-[(4-methylcyclohex-3-enylcarbonyl)amino]-4-oxo-3,4-dihydroquinazolin-2-yl}propanoic acid. Optimal conditions for obtaining of the starting acid have been established, and anilides have been synthesized by the mixed anhydrides method.

Authors: D. Zicane, I. Ravina, Z. Tetere, and I. Rijkure.

English translation in Chemistry of Heterocyclic Compounds, 2012, 48 (2), pp 358-361

http://link.springer.com/article/10.1007/s10593-012-0997-z