SYNTHESIS AND PROPERTIES OF PYRAZOLE CARBALDEHYDE BIS(2-HYDROXYETHYL)DITHIOACETAL HYDROCHLORIDES

Authors

  • Л. К. Паперная A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • А. А. Шатрова A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • А. И. Албанов A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • Е. В. Рудякова A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences
  • Г. Г. Левковская A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences

DOI:

https://doi.org/10.1007/1350

Keywords:

bis(2-hydroxyethyl)dithioacetals, 2-mercaptoethanol, 1, 3-oxathiolane, pyrazole carbaldehydes, trimethylchlorosilane, acetalization

Abstract

A simple method has been developed for the synthesis of water-soluble pyrazole derivatives, namely 4-[bis(2-hydroxyethylsulfanyl)methyl]pyrazoles hydrochlorides, by the reaction of a series of pyrazole carbaldehydes with 2-mercaptoethanol in the presence of trimethylchlorosilane. When treated with aqueous ammonia solution the pyrazole-4-carbaldehydes bis(2-hydroxyethyl)dithioacetal hydro-chlorides are converted to the 4-[bis(2-hydroxyethylsulfanyl)methyl]pyrazole free bases.

Authors: L. K. Papernaya, A. A. Shatrova, A. I. Albanov, E. V. Rudyakova, and G. G. Levkovskaya.

English translation in Chemistry of Heterocyclic Compounds, 2011, 47 (11), pp 1395-1404

http://link.springer.com/article/10.1007/s10593-012-0927-0

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Published

2013-12-12

Issue

No. 11 (2011)

Section

Original Papers