STUDY OF THREE-COMPONENT REACTIONS BETWEEN 5-AMINO-3-METHYLISOXAZOLE, <i>N</i>-ARYLAMIDES OF ACETOACETIC ACID, AND AROMATIC ALDEHYDES
DOI:
https://doi.org/10.1007/1822Keywords:
5-amino-3-methylisoxazole, N-arylcarboxamide, isoxazolo[5, 4-b]pyridine, heterocyclization, three-component reaction, ultrasonicationAbstract
A three-component cyclocondensation between 5-amino-3-methylisoxazole, N‑arylamides of aceto-acetic acid, and aromatic aldehydes was studied under the conditions of thermal activation and ultrasonication. Upon heating in n-butanol, depending on the substituent in aldehyde, the reaction produced either N,4‑diaryl-3,6-dimethylisoxazolо[5,4-b]pyridine-5-carboxamides, or their 4,7‑dihydro derivatives. Ultrasonication unexpectedly produced N1,N3,2-triaryl-4-hydroxy-4-methyl-6-oxocyclo-hexane-1,3-dicarboxamides.
How to Cite
Tkachenko, V. V.; Muravyova, E. A.; Shishkina, S. V.; Shishkin, O. V.; Desenko, S. M.; Chebanov, V. A. Chem. Heterocycl. Compd. 2014, 50, 1166. [Khim. Geterotsikl. Soedin. 2014, 1263.]
For this article in the English edition see DOI 10.1007/s10593-014-1578-0
