FACILE AND RAPID SYNTHESIS OF 5-SUBSTITUTED 1<i>H</i>-TETRAZOLES <i>via</i> A MULTICOMPONENT DOMINO REACTION USING NICKEL(II) OXIDE NANOPARTICLES AS CATALYST
DOI:
https://doi.org/10.1007/1832Keywords:
NiO nanoparticles, 2-(1H-tetrazol-5-yl)acrylonitrile, 1, 3-dipolar cycloaddition, Knoevenagel condensationAbstract
2-(1H-Tetrazol-5-yl)acrylonitrile derivatives were synthesized through multicomponent domino Knoevenagel condensation/1,3-dipolar cycloaddition reaction of carbonyl compounds, malononitrile, and sodium azide in the presence of NiO nanoparticles as a highly efficient catalyst. This method has the advantage of very short reaction times, high yields, simple methodology, and easy work-up. The catalyst can be recovered and reused while maintaining good yields.
How to Cite
Safaei-Ghomi, J.; Paymard-Samani, S. Chem. Heterocycl. Compd. 2015, 50, 1567. [Khim. Geterotsikl. Soedin. 2014, 1706.]
For this article in the English edition see DOI 10.1007/s10593-014-1625-x
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Published
2014-11-04
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Original Papers