AN EFFICIENT SOLVENTLESS SYNTHESIS OF CYCLOALKENO-1,2,3-SELENADIAZOLES, THEIR ANTIMICROBIAL STUDIES, AND COMPARISON WITH PARENT SEMICARBAZONES

Authors

  • Aditi A. Jadhav Nanochemistry Laboratory, Department of Applied Chemistry, Defence Institute of Advanced Technology (DIAT), Ministry of Defence, DRDO, Govt. of India, Girinagar, Pune - 411 025
  • Vaishali P. Dhanwe Nanochemistry Laboratory, Department of Applied Chemistry, Defence Institute of Advanced Technology (DIAT), Ministry of Defence, DRDO, Govt. of India, Girinagar, Pune - 411 025
  • Prasad G. Joshi Nanochemistry Laboratory, Department of Applied Chemistry, Defence Institute of Advanced Technology (DIAT), Ministry of Defence, DRDO, Govt. of India, Girinagar, Pune - 411 025
  • Pawan Kumar Khanna Nanochemistry Laboratory, Department of Applied Chemistry, Defence Institute of Advanced Technology (DIAT), Ministry of Defence, DRDO, Govt. of India, Girinagar, Pune - 411 025

DOI:

https://doi.org/10.1007/2054

Keywords:

organoselenium compounds, selenadiazoles, semicarbazones, grinding, solventless synthesis

Abstract

A series of heterocyclic organoselenium compounds, cycloalkeno-1,2,3-selenadiazoles (cyclopenteno, cyclohexeno, cyclohepteno, and cycloocteno-1,2,3-selenadiazoles), was synthesized at room temperature in one step under solventless conditions from the corresponding semicarbazones. The synthesized 1,2,3-selenadiazoles and their parent  semicarbazones were screened for their antimicrobial activity
against various pathogenic bacteria using agar disc diffusion method. All compounds were found active against E. coli, S. aureus, S. typhi, and P. aeruginosa. Among all the tested selenadiazoles, cyclopenteno-1,2,3-selenadiazole showed excellent inhibition against highly resistant P. aeruginosa. It is observed that selenadiazoles showed higher activity compared with the respective semicarbazones.

How to Cite
Jadhav, A. A.; Dhanwe, V. P.; Joshi, P. G.; Khanna, Pawan K. Chem. Heterocycl. Compd. 2015, 51, 102. [Khim. Geterotsikl. Soedin. 2015, 51, 102.]

For this article in the English edition see DOI 10.1007/s10593-015-1666-9

 

Author Biographies

Aditi A. Jadhav, Nanochemistry Laboratory, Department of Applied Chemistry, Defence Institute of Advanced Technology (DIAT), Ministry of Defence, DRDO, Govt. of India, Girinagar, Pune - 411 025

PhD Senior Research scholar

Pawan Kumar Khanna, Nanochemistry Laboratory, Department of Applied Chemistry, Defence Institute of Advanced Technology (DIAT), Ministry of Defence, DRDO, Govt. of India, Girinagar, Pune - 411 025

Applied Chemistry

Downloads

Published

2015-02-03

Issue

Vol. 51 No. 1 (2015)

Section

Original Papers