A SIMPLE AND EFFICIENT SYNTHESIS OF SUBSTITUTED PYRAZOLES
DOI:
https://doi.org/10.1007/228Keywords:
1, 3-diphenyl-1H-pyrazole, potassium hydroxide, pyrazole-5-carbonitrile, phase transfer catalyst, tetrabutylammonium bromide, X-ray studyAbstract
A novel route for the formation of 3-aryl-1-phenyl-1H-pyrazoles was discovered upon the reaction of 3-aryl-1-phenyl-4,5-dihydro-1H-pyrazole-5-carbonitrile with potassium hydroxide in the presence of phase transfer catalyst (tetrabutylammonium bromide) in THF as a solvent and a single crystal X-ray study is reported.
Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (5), pp 698-703
http://link.springer.com/article/10.1007/s10593-013-1300-7